منابع مشابه
Myosin-I nomenclature
We suggest that the vertebrate myosin-I field adopt a common nomenclature system based on the names adopted by the Human Genome Organization (HUGO). At present, the myosin-I nomenclature is very confusing; not only are several systems in use, but several different genes have been given the same name. Despite their faults, we believe that the names adopted by the HUGO nomenclature group for geno...
متن کاملMyosin I
Phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) is a key signaling molecule in chemotaxis, a directed cell migration toward chemoattractants. PtdIns(3,4,5)P(3) is transiently generated by chemotactic stimulation and activates reorganization of the actin cytoskeleton at the leading edge of migrating cells. In a recent study, we demonstrated that PtdIns(3,4,5)P(3) directly binds to t...
متن کاملGenetic evidence that Acanthamoeba myosin I is a true myosin.
Acanthamoeba castellanii contains two enzymes, myosins IA and IB, that exhibit the catalytic properties of a myosin but possess very unusual physical properties, the most striking of which are their single, low molecular weight heavy chain, their globular shape, and their inability to form bipolar filaments. We have now isolated a putative myosin IB heavy chain gene from Acanthamoeba, using as ...
متن کاملMammalian myosin I alpha, I beta, and I gamma: new widely expressed genes of the myosin I family
A polymerase chain reaction strategy was devised to identify new members of the mammalian myosin I family of actin-based motors. Using cellular RNA from mouse granular neurons and PC12 cells, we have cloned and sequenced three 1.2-kb polymerase chain reaction products that correspond to novel mammalian myosin I genes designated MMI alpha, MMI beta, MMI gamma. The pattern of expression for each ...
متن کاملOverlapping functions of myosin-I isoforms?
S INCE the discovery of myosin-I (MI) 1 in Acanthamoeba (32), DNA cloning and/or biochemical purification have established the presence of multiple MI isoforms in nearly every eukaryotic cell examined. Despite intensive study, the physiological role of these actin-based, molecular motors has remained a mystery, in large part, because cells express several isoforms of MI with similar biochemical...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2001
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.200110032